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潜在的に深刻な副作用は他のオピオイドと同様に呼吸抑制である。この抑制は用量依存であり、この呼吸抑制が過量服用時に深刻な結果をもたらす。

投与方法は経口で、形状は錠、散、シロップがある。錠剤ではコデインはしばしばアセトアミノフェン、アスピリン、イブプロフェンと共に調合される。これらの組み合わせは、それぞれ単体での使用よりも良い疼痛コントロールが可能となる。

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To the part of the musculoskeletal program: muscle fasciculations, cramps, pain in muscles and joints, swelling of joints, muscle stiffness, soreness in back again and limbs. In a few scenarios mentioned the development of spasm in the neck muscles and rhabdomyolysis.

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Due to these pitfalls, reserve concomitant prescribing of those medicines in individuals for whom alternate treatment choices are insufficient.

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